Augmentin (Amoxicillin Trihydrate/Potassium Clavulanate) - 500mg/125mg (20 Tablets)
- Brand: Augmentin
- Generic / Active Ingredient: Amoxicillin | Potassium Clavulanate |
- Manufacturer: GlaxoSmithKline
- Availability: A
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Brand Name : Augmentin
Generic Name: Amoxicillin | Potassium Clavulanate |
Manufacturer : GlaxoSmithKline
(Amoxicillin Trihydrate/Potassium Clavulanate) is a semisynthetic beta lactam antibiotic that is produced from a combination of 2 different ingredients; amoxicillin (a penicillin) and clavulanic acid. The drug is classified as a broad spectrum antibiotic medicine against both gram negative and gram positive bacterial micro-organisms which cause infections.
How to use Augmentin
Mechanism of drug action
Amoxicillin alone is not effective in the management of some of the infections caused by bacteria that produce beta lactamase enzymes. These enzymes inactivate the drug by inhibiting the beta lactam ring found on amoxicillin. Combining amoxicillin with a beta lactamase inhibitor such as clavulanic acid (in the form of potassium clavulanate) therefore helps counter the resistance to the beta lactamase producing organisms. Clavulanic acid acts on the beta lactamase enzymes that occur in these organisms to inhibit them, blocking enzyme activity on amoxicillin enabling the penicillin have its antibiotic effect through impairing bacterial cell wall synthesis.
Augmentin therefore has an extended spectrum of activity compared to amoxicillin alone to include many microorganisms which would otherwise be resistant to treatment. Indications include infections of the soft tissue or skin, urinary tract infections, strep throat, bronchitis, pneumonia and other lower respiratory tract infections, ear infections, sinusitis and other bacterial infections.
Augmentin (Amoxicillin Trihydrate/Potassium Clavulanate) is in form tablets which are swallowed whole with a glass of water. Do not crush or chew the extended release tablet. The dosage usually varies according to the patient`s symptoms and their medical history. For patients being treated for mild to moderate infections, physicians usually prescribe 1 tablet twice a day.
However for serious and complicated urinary tract infections, infections of the lower respiratory tract and other types of infections the physician may prescribe 1 to 2 tablets administered 3 times a day. The duration of treatment with Augmentin will be decided upon by the physician and in all cases it is the patient’s obligation to fully comply with the instructions given by the doctor. You are also advised to follow all directions on your prescription label.
Augmentin Side Effects
Minor side effects of Augmentin include diarrhea, stomach discomfort and vomiting, itchiness, and vaginal or oral thrush. Augmentin (Amoxicillin Trihydrate/Potassium Clavulanate) has also been associated with the occurrence of colitis (a condition which causes inflammation of the bowel). Should you suffer from serious or bloody diarrhea, bruising and bleeding, seizures, abnormal behavior, and dark discoloration of urine or any serious adverse events which have not been referenced in this paragraph during the treatment process or when treatment has stopped, don’t hesitate to consult your physician as soon as possible. You should stop using the drug immediately and visit the hospital straight away for examination.
If you suffer from any impairment of the kidney or the liver function, your physician will closely monitor you for the entire duration of treatment to avoid drug toxicity. Liver toxicity is usually reversible if diagnosed early. You should also be careful to report any hypersensitivity reactions such as skin rashes and/or fever noted during treatment.